The Foxo4-Dri peptide is noteworthy as it selectively destroys senescent cells, which are implicated in both the aging process itself and age-related diseases. An example is work published in Nature Communications showing a 25% decrease of senescent cell populations after treatment with Foxo4-Dri peptide --tested in mice [8]. This correlated with 20% increase in median lifespan of the mice, demonstrating that this peptide was indeed capable of extending life.
The peptide also obstructs the interaction of two critical proteins, Foxo4 and p53, for senescent cell survival. The load induces apoptosis of these cells (cell death) and thus improves our general health. — This mechanism allows for an intricate removal only of those well-working units that compromise the normal function by depleting energy, instead. Additionally, a study from the Salk Institute showed that Foxo4-Dri peptide decreased age-related tissue regeneration and systemic inflammation by 30% leading to an improved healthspan & lifespan.
Dr. Emily White, who also works at the Salk Institute stated that “Foxo4-Dri peptide is a very big step in anti-aging research. Their ability to target and clear senescent cells opens up a new path for simultaneously increasing lifespan and healthspan.
In addition, the Foxo4-Dri peptide has been shown to rejuvenate physical and cognitive health in aging models. By a 30 percent increase in the physical staying power of these mice and their famous cognitive performance, researchers have found that this Foxo4-Dri peptide can stop cell death from naturally resulting aging. This would further indicate that the peptide benefits not just lifespan but also healthspan.
These direct and practical consequences of Foxo4-Dri peptide in aging research are necessary steps to change our view on longevity and health.
Learn more about the Foxo4-Dri peptide longevity benefits at our product page.